NUCLEOFILL™ MEDIUM PLUS

NUCLEOFILL™ MEDIUM PLUS Product Summary

NUCLEOFILL™ MEDIUM PLUS is a cutting-edge bio-restructuring injectable gel designed for skin revitalization and repair. It features natural polynucleotides formulated for deeper hydration, anti-aging effects, and tissue regeneration. This advanced product targets oxidative stress and signs of aging, delivering significant improvements in skin elasticity and tone.

• Type: Polynucleotide-based bio-stimulant gel.
• Intended Use: Facial and body skin rejuvenation.
• Packaging: Supplied in sterile, pre-filled syringes.

NUCLEOFILL™ MEDIUM PLUS Key Features and Benefits

This product offers comprehensive skin enhancement through hydration, regeneration, and protection.

• Hydration: Deep and prolonged water-binding capability enhances skin moisture levels.
• Antioxidant Properties: Neutralizes free radicals, reducing oxidative stress.
• Fibroblast Stimulation: Increases collagen and elastin production for improved dermal structure.
• Regenerative Action: Promotes cellular renewal and tissue repair.
• Elasticity Restoration: Provides a subtle lifting effect by activating myofibroblasts.

NUCLEOFILL™ MEDIUM PLUS Composition

NUCLEOFILL™ MEDIUM PLUS uses high-purity ingredients optimized for maximum efficacy.

• Polynucleotide Concentration: 2.5%.
• Molecular Weight: 2,500 kDa for effective dermal bioavailability.
• Viscosity: 48–65 Pa*s, ensuring precise application and integration into tissues.

NUCLEOFILL™ MEDIUM PLUS Intended Purpose / Indications

This product is suitable for a wide range of skin rejuvenation applications.

• Indications:
  • Severe wrinkles and sagging skin.
  • Skin damaged by oxidative stress.
  • Atrophic scars, including acne scars.
• Targeted Treatment Areas:
  • Face: Cheeks, nasolabial folds, and jawline.
  • Body: Décolleté, neck, and hands.

NUCLEOFILL™ MEDIUM PLUS Injection and Treatment Areas

It is formulated for deep and targeted rejuvenation, suitable for various treatment zones.

• Recommended Injection Areas:
  • Facial zones like periorbital regions and jawline.
  • Neck and chest for elasticity improvements.
  • Hands for volume and texture restoration.
• Injection Depth: Delivered into the dermis or subcutaneous layers, depending on the treatment objective.

NUCLEOFILL™ MEDIUM PLUS Reconstitution and Preparation Guidelines

The product comes pre-filled and requires no additional preparation, ensuring convenience and sterility.

• Preparation Guidelines:
  • Open the sterile packaging in an aseptic environment.
  • Attach the included 30G needle securely to the syringe.
  • Inspect the solution to ensure no particulates are present before injection.

NUCLEOFILL™ MEDIUM PLUS Administration and Dosage

Proper administration is crucial for achieving optimal results while minimizing risks.

• Injection Techniques:
  • Use multi-puncture or linear threading methods based on the area.
  • Deliver approximately 0.1 mL per point at intervals of 1 cm.
• Dosage:
  • A typical session requires 1.5 mL per area, depending on the extent of treatment.
  • Initial treatments involve 3 sessions spaced 15–30 days apart.

NUCLEOFILL™ MEDIUM PLUS Storage Instructions

Correct storage ensures the product’s efficacy and safety.

• Store at 2–30°C in a dry, light-protected environment.
• Avoid freezing and ensure the package remains sealed until use.
• Always verify the expiration date before administration.

NUCLEOFILL™ MEDIUM PLUS Contraindications

Specific conditions must be considered to avoid adverse effects.

• Not Suitable For:
  • Patients allergic to polynucleotides or related components.
  • Areas with active infections or inflammation.
  • Pregnant or breastfeeding individuals.
  • Patients with autoimmune disorders or severe chronic illnesses.

NUCLEOFILL™ MEDIUM PLUS Precautions and Warnings

Strict adherence to safety precautions ensures successful outcomes.

• Avoid injecting near blood vessels to minimize risks of intravascular complications.
• Do not mix with other injectables or undergo simultaneous aesthetic procedures.
• Thorough patient consultation is necessary to assess suitability and risks.

NUCLEOFILL™ MEDIUM PLUS Post-Treatment Care

Post-treatment guidelines promote optimal healing and results.

• Care Instructions:
  • Avoid UV exposure, extreme temperatures, and physical exertion for 48 hours.
  • Use soothing, non-comedogenic skincare products.
  • Apply SPF 50 sunscreen daily to protect treated areas.

NUCLEOFILL™ MEDIUM PLUS Side Effects and Adverse Reactions

The product is well-tolerated, with minimal side effects reported.

• Common Side Effects:
  • Redness, mild swelling, and tenderness at injection sites.
  • Temporary bruising or itching.
• Rare Reactions:
  • Formation of small nodules or discoloration that resolve with time.

NUCLEOFILL™ MEDIUM PLUS Patient Eligibility

This product is suitable for adults seeking comprehensive skin rejuvenation.

• Ideal Candidates:
  • Adults with moderate to severe skin aging or oxidative damage.
  • Those seeking non-invasive solutions for volume and elasticity improvement.
• Not recommended for individuals under 18 years or with unrealistic expectations.

NUCLEOFILL™ MEDIUM PLUS Follow-Up and Maintenance

A consistent treatment protocol ensures sustained and enhanced results.

• Follow-Up Schedule:
  • Initial treatment series of 3 sessions every 2–4 weeks.
  • Maintenance sessions every 4–6 months, depending on patient needs.

NUCLEOFILL™ MEDIUM PLUS Manufacturer and Regulatory Information

NUCLEOFILL™ MEDIUM PLUS is produced by Biosimil Aesthetics, a leader in polynucleotide-based solutions.

• Manufacturer: Biosimil Aesthetics.
• Certifications: CE-marked for safety and efficacy in skin rejuvenation.